Restart your HPG axis after a cycle. SERMs, aromatase inhibitors, gonadotropins, prolactin control — sequenced.
PCT (post-cycle therapy) restores endogenous testosterone production after anabolic-androgenic steroid use. The four classes used: SERMs (Clomid, Nolvadex, Raloxifene, Enclomiphene) restart the hypothalamic-pituitary-gonadal axis; AIs (Arimidex, Aromasin, Letrozole) control estrogen rebound; gonadotropins (HCG, HMG) maintain testicular function on-cycle and accelerate restart; cabergoline manages prolactin from 19-nor compounds and GH peptides.
PCT protocols are highly compound- and dose-dependent. The classic 4-week post-cycle SERM block is appropriate for mild cycles; long, suppressive cycles need a longer, layered approach.
Human Chorionic Gonadotropin · Pregnyl · Novarel
LH analogue. Mimics LH to maintain testicular function on TRT or restart after a cycle.
Clomiphene Citrate · Serophene
The original SERM PCT. Two isomers — one helpful, one notorious for emotional side effects.
Femara
The most potent AI. Crushes estrogen — useful for emergency gyno, dangerous for general use.
Anastrozole
Aromatase inhibitor. The stronger, surgical AI for high-dose AAS cycles.
Evista · Keoxifene
SERM. Stronger anti-estrogen action in breast tissue. The gyno-reversal compound.
Tamoxifen Citrate
SERM. Gold standard for gynecomastia prevention and PCT — gentler than Clomid emotionally.
Caber · Dostinex
Dopamine D2 agonist. Crushes prolactin from 19-nor compounds and GH peptides.
Exemestane
Suicide AI — permanently inactivates aromatase. No estrogen rebound on discontinuation.
Trans-clomiphene · Androxal
The clean half of Clomid. Pure trans-isomer — endogenous testosterone without the side effects.
Human Menopausal Gonadotropin · Menopur
Mixed LH/FSH gonadotropin. Used for full HPG restart and fertility — the FSH-side of HCG.
| Clomid | Nolvadex | Arimidex | HCG | |
|---|---|---|---|---|
| Use case | PCT restart | PCT restart | On-cycle E2 | On-cycle T |
| Side effects | Mood swings, vision | Mild, IGF-1↓ | Joints, lipids | Estrogen rise |
| PCT dose | 50/50/25/25 mg | 20/20/10/10 mg | 0.25-0.5 mg E3D | 500 IU 2x/wk |
For short esters (propionate, NPP), 3 days after last injection. For long esters (cypionate, enanthate), 14 days after. For deca, 21 days. HCG can be run on-cycle or just before PCT to accelerate restart.
Usually no. AI use should be guided by sensitive E2 bloodwork, not preemptive dosing. Crushed estrogen has worse symptoms than mildly elevated estrogen (joints, libido, mood).
HCG alone (LH-only signal) is enough for testicular size and testosterone. HCG + HMG (LH + FSH) is needed when spermatogenesis must restart, typically after prolonged suppression.
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